Endocrine Abstracts

Adrenal cortical carcinoma (ACC) is a rare malignancy, especially in children, and the annual worldwide incidence has been calculated as 0.3 cases per million children younger than 15 years old. We present a case of functioning ACC in a 7 years-old female child who manifested with virilization. She presented with low-pitched voice, excessive pubic hair growth, growth acceleration, clitoral enlargement and increased muscle strength at the age of six. Her blood pressure was norm...

Back ground: Numerous researches indicate that DHEA administration decreases fat mass in human and rodent. We evaluated the effects of DHEA treatment on adiposity. Male Otsuka Long evans fatty (OLETF) rats, hereditary obese type 2 diabetic animals derived from long evans tokushima (LETO) rats. These rats were fed with or without (control) 0.4% DHEA containing food for 52 weeks. Telomere length as a marker of whole cell division in adipose tissue were assessed. Genomic DNA isol...